4 LATEST ADVANCEMENTS IN THE TREATMENT OF DIABETES- NO INJECTIONS, NO PILLS- FUTURE OF THE DIABETES TREATMENT

1. Is It Possible To Treat Diabetes Without Injections Or Drugs? 

Are you a diabetic and fed up pricking your finger again and again? What if you know there may be an actual treatment, without any injection or drugs, of diabetes in the coming future?

Diabetes is a metabolic disorder sparing no gender or ethnicity around the world. 382 million people around the world had this disease in 2013 which rose to 425 million in 2017.1,2

If you are diabetic, you may already familiar with the type of diabetes.

• Type 1 Diabetes-Also known as insulin-dependent diabetes. It is due to insufficient insulin production by the body.

• Type 2 Diabetes-90 % of diabetic patients have this condition.3 

It is a non- insulin-dependent form of the disease mainly due to weight gain. The body produces insulin but the cells fail to respond.

Let’s have a look at the latest advancements in the treatment of diabetes that can revolutionise the future.

1.1 The Cellular Re-Programming For Insulin Production

The cause of type 1 diabetes is the auto-immune attack of the body on specific types of cells of the pancreas known as beta cells. This almost destroys the group of beta cells leading to the diminished production of insulin.

One of the ongoing researches is to re-program another cell type of pancreas for the production of insulin. These cells are called alpha cells. One study in mice has shown some positive results. This technique needs trials and further investigation to become a real clinical intervention.4

1.2 Circadian (Biological) Rhythms and Environmental Implications

Circadian rhythms are biological cycles that are affected by light and darkness. Our body knows how to interpret the day and the night. A disturbed circadian rhythm can lead to metabolic disorders like diabetes. 4

Scientists are trying to understand the biological clock of the body and its effects on the hormonal changes. So in the future, your doctor can advise a certain sleep cycle, diet, and exercise pattern in a more precise way to prevent diabetes.

1.3. The Gut Microbes Role in Diabetes

Recent studies have shown that microbes in gut play a vital role in insulin resistance development in type 2 diabetic patients.4 

A study compared the level of an amino-acid product that is produced by a certain microbe possibly involved in insulin resistance. They found that type 2 diabetic obese persons had higher amounts of this metabolite in their blood than healthy individuals.5

Therefore, In the future, there can be therapies for type 2 diabetes for change in the microbe type in your gut. The clinical trials for these treatments are already in process.

1.4 The Needle-Free Glucose Check- No Pricking

This technology is not of the late future. Companies are developing devices which can detect blood glucose level without pricking. One of such product has already hit the European markets namely “GlucoTrack”. This device uses electromagnetic wave detection.

Another similar product, using laser technology “GlucoSense”, is now approaching the markets.

2. What Is The Future Of The Diabetes Treatment?

With ongoing research in cellular biology, genetics, epidemiology, and other medical sciences, one thing is anticipated that there will be more diabetic patients in the future due to the change in the lifestyle.

The good news is that parallel research for the cure of this disease is also showing promising results. You can have cellular therapy or some chip attached to your body in a single clinical visit in the future that will make you free from painful insulin shots and never-ending range of tablets. 

References

• Statista- https://www.statista.com/statistics/271442/number-of-diabetics-worldwide/

• Shi Y, Hu FB. The global implications of diabetes and cancer. Lancet. 2014;383(9933):1947-1948. doi:10.1016/S0140-6736(14)60886-2

• Vos, Theo et al. “Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.” Lancet (London, England) vol. 380,9859 (2012): 2163-96. doi:10.1016/S0140-6736(12)61729

• Zierath, J.R. Major Advances and Discoveries in Diabetes – 2019 in Review. Curr Diab Rep 19, 118 (2019). https://doi.org/10.1007/s11892-019-1255-x

• Koh A, Molinaro A, Stahlman M, et al. Microbially produced imidazole propionate impairs insulin signaling through mtorc1. Cell. 2018;175:947–961 e917.